Antigenicity of a protective recombinant filarial protein in human bancroftian filariasis.
Identifieur interne : 00D168 ( Main/Exploration ); précédent : 00D167; suivant : 00D169Antigenicity of a protective recombinant filarial protein in human bancroftian filariasis.
Auteurs : J W Kazura [États-Unis] ; F E Hazlett ; E. Pearlman ; K. Day ; A. El-Zeiny ; T W Nilsen ; M P AlpersSource :
- The Journal of infectious diseases [ 0022-1899 ] ; 1992.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Animaux, Antigènes d'helminthe (immunologie), Brugia malayi (immunologie), Enfant, Filariose lymphatique (immunologie), Humains, Immunoglobuline E (sang), Immunoglobuline G (sang), Microfilaria (immunologie), Papouasie - Nouvelle-Guinée, Protéines recombinantes (immunologie), Réactions croisées, Test ELISA, Wuchereria bancrofti (immunologie), Égypte.
- MESH :
English descriptors
- KwdEn :
- Adolescent, Adult, Animals, Antigens, Helminth (immunology), Brugia malayi (immunology), Child, Cross Reactions, Egypt, Elephantiasis, Filarial (immunology), Enzyme-Linked Immunosorbent Assay, Humans, Immunoglobulin E (blood), Immunoglobulin G (blood), Microfilariae (immunology), Papua New Guinea, Recombinant Proteins (immunology), Wuchereria bancrofti (immunology).
- MESH :
- chemical , blood : Immunoglobulin E, Immunoglobulin G.
- chemical , immunology : Antigens, Helminth, Recombinant Proteins.
- immunology : Brugia malayi, Elephantiasis, Filarial, Microfilariae, Wuchereria bancrofti.
- Adolescent, Adult, Animals, Child, Cross Reactions, Egypt, Enzyme-Linked Immunosorbent Assay, Humans, Papua New Guinea.
Abstract
A 92-kDa fusion protein that encodes amino acids 1-479 of a 62-kDa Brugia malayi antigen induces resistance to microfilariae in mice. The antigenicity of this recombinant protein was explored in asymptomatic residents of Wuchereria bancrofti-endemic areas of Papua New Guinea and Egypt. Unlike sera from individuals in nonendemic areas, sera from residents of endemic areas contained IgG3 antibodies (up to dilution 1:1280) reactive with the fusion protein. There was little or no recombinant antigen-specific IgG1, IgG2, IgG4, or IgE. The mean level of IgG3 antibodies to the amino acid 1-479 construct in sera of putatively "immune" adult Papua New Guineans and children in whom microfilaremia was < 4 parasites/mL of blood was not significantly different (P < .05) from those with > 1000 parasites/mL. These data indicate that the filarial antigen corresponding to the recombinant protein is highly immunogenic in naturally infected children and adults and that the isotype and magnitude of antibody reactivity with it do not correlate with the microfilaremic status of asymptomatic persons.
PubMed: 1431265
Affiliations:
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Pearlman</name></author><author><name sortKey="Day, K" sort="Day, K" uniqKey="Day K" first="K" last="Day">K. Day</name></author><author><name sortKey="El Zeiny, A" sort="El Zeiny, A" uniqKey="El Zeiny A" first="A" last="El-Zeiny">A. El-Zeiny</name></author><author><name sortKey="Nilsen, T W" sort="Nilsen, T W" uniqKey="Nilsen T" first="T W" last="Nilsen">T W Nilsen</name></author><author><name sortKey="Alpers, M P" sort="Alpers, M P" uniqKey="Alpers M" first="M P" last="Alpers">M P Alpers</name></author></analytic><series><title level="j">The Journal of infectious diseases</title><idno type="ISSN">0022-1899</idno><imprint><date when="1992" type="published">1992</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Animals</term><term>Antigens, Helminth (immunology)</term><term>Brugia malayi (immunology)</term><term>Child</term><term>Cross Reactions</term><term>Egypt</term><term>Elephantiasis, Filarial (immunology)</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Humans</term><term>Immunoglobulin E (blood)</term><term>Immunoglobulin G (blood)</term><term>Microfilariae (immunology)</term><term>Papua New Guinea</term><term>Recombinant Proteins (immunology)</term><term>Wuchereria bancrofti (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Animaux</term><term>Antigènes d'helminthe (immunologie)</term><term>Brugia malayi (immunologie)</term><term>Enfant</term><term>Filariose lymphatique (immunologie)</term><term>Humains</term><term>Immunoglobuline E (sang)</term><term>Immunoglobuline G (sang)</term><term>Microfilaria (immunologie)</term><term>Papouasie - Nouvelle-Guinée</term><term>Protéines recombinantes (immunologie)</term><term>Réactions croisées</term><term>Test ELISA</term><term>Wuchereria bancrofti (immunologie)</term><term>Égypte</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Immunoglobulin E</term><term>Immunoglobulin G</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Helminth</term><term>Recombinant Proteins</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes d'helminthe</term><term>Brugia malayi</term><term>Filariose lymphatique</term><term>Microfilaria</term><term>Protéines recombinantes</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Brugia malayi</term><term>Elephantiasis, Filarial</term><term>Microfilariae</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Immunoglobuline E</term><term>Immunoglobuline G</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Animals</term><term>Child</term><term>Cross Reactions</term><term>Egypt</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Humans</term><term>Papua New Guinea</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Animaux</term><term>Enfant</term><term>Humains</term><term>Papouasie - Nouvelle-Guinée</term><term>Réactions croisées</term><term>Test ELISA</term><term>Égypte</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A 92-kDa fusion protein that encodes amino acids 1-479 of a 62-kDa Brugia malayi antigen induces resistance to microfilariae in mice. The antigenicity of this recombinant protein was explored in asymptomatic residents of Wuchereria bancrofti-endemic areas of Papua New Guinea and Egypt. Unlike sera from individuals in nonendemic areas, sera from residents of endemic areas contained IgG3 antibodies (up to dilution 1:1280) reactive with the fusion protein. There was little or no recombinant antigen-specific IgG1, IgG2, IgG4, or IgE. The mean level of IgG3 antibodies to the amino acid 1-479 construct in sera of putatively "immune" adult Papua New Guineans and children in whom microfilaremia was < 4 parasites/mL of blood was not significantly different (P < .05) from those with > 1000 parasites/mL. These data indicate that the filarial antigen corresponding to the recombinant protein is highly immunogenic in naturally infected children and adults and that the isotype and magnitude of antibody reactivity with it do not correlate with the microfilaremic status of asymptomatic persons.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Ohio</li></region></list><tree><noCountry><name sortKey="Alpers, M P" sort="Alpers, M P" uniqKey="Alpers M" first="M P" last="Alpers">M P Alpers</name><name sortKey="Day, K" sort="Day, K" uniqKey="Day K" first="K" last="Day">K. Day</name><name sortKey="El Zeiny, A" sort="El Zeiny, A" uniqKey="El Zeiny A" first="A" last="El-Zeiny">A. El-Zeiny</name><name sortKey="Hazlett, F E" sort="Hazlett, F E" uniqKey="Hazlett F" first="F E" last="Hazlett">F E Hazlett</name><name sortKey="Nilsen, T W" sort="Nilsen, T W" uniqKey="Nilsen T" first="T W" last="Nilsen">T W Nilsen</name><name sortKey="Pearlman, E" sort="Pearlman, E" uniqKey="Pearlman E" first="E" last="Pearlman">E. Pearlman</name></noCountry><country name="États-Unis"><region name="Ohio"><name sortKey="Kazura, J W" sort="Kazura, J W" uniqKey="Kazura J" first="J W" last="Kazura">J W Kazura</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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